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id="i2i2jyu4k" class="pv_box m_p ov_hi"> <div id="i2i2jyu4k" class="bw_750 fl"> <h1 class="pv_title_2"><span id="i2i2jyu4k" class="site fr"><a href='/'>首页</a>><a href='/xywy/'>寻医·问药</a>><a href='/xywy/jkst/'>健康识堂</a></span><span id="i2i2jyu4k" class="t" id="a1"><a href="/xywy/jkst/">健康识堂</a></span></h1> <div id="i2i2jyu4k" class="pa_0_5_0_10"> <h1 class="Content_title" id="hh"> <span id="a" style="">关注卵巢癌防治加速临床急需抗癌新药纳入医保</span> </h1> <script>/*jQuery('#hh').width(jQuery('#a').width());*/</script> <div id="i2i2jyu4k" class="Remark"> <span>2019年03月14日 19:22 | 作者:孙慧肖寒 | 来源：<a target="_blank">新华网</a></span> <span id="i2i2jyu4k" class="fr"> <div id="i2i2jyu4k" class="bdsharebuttonbox"><a href="#" class="bds_more" data-cmd="more"></a><a href="#" class="bds_qzone" data-cmd="qzone" title="分享到QQ空间"></a><a href="#" class="bds_tsina" data-cmd="tsina" title="分享到新浪微博"></a><a href="#" class="bds_tqq" data-cmd="tqq" title="分享到腾讯微博"></a><a href="#" class="bds_renren" data-cmd="renren" title="分享到人人网"></a><a href="#" class="bds_weixin" data-cmd="weixin" title="分享到微信"></a></div> <script>window._bd_share_config={"common":{"bdSnsKey":{},"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":"0","bdSize":"16"},"share":{}};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')).src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];</script> </span><span id="i2i2jyu4k" class="fr">分享到：<img src="/images/fx.jpg" /> </span> </div> <div id="i2i2jyu4k" class="text_box"> <p align="center"> <p style="text-indent: 2em; text-align: left;">新华网北京3月12电（孙慧肖寒）在妇科肿瘤中，卵巢癌的发病率虽然低于宫颈癌和子宫内膜癌，但死亡率却高于后两者，为什么卵巢癌的恶性程度如此之高呢？近日，中国医学科学院肿瘤医院妇瘤科主任，北京协和医学院妇产科学系副主任、博士生导师吴令英教授做客新华网时表示，由于卵巢癌很难早期发现，且易复发，故死亡率很高。近年来，随着肿瘤的治疗方法不断的创新，对于铂敏感复发的卵巢癌患者，PARP抑制剂为治疗提供了新路径。</p><p style="text-align:center"><img id="{71BC7B1B-052C-4827-ADC9-32A3D551CA4E}" title="" border="0" src="http://www.xinhuanet.com/health/2019-03/12/1124221652_15522967288361n.jpg" sourcedescription="编辑提供的本地文件" sourcename="本地文件" style="border-width: initial; vertical-align: middle; margin: 10px 0px; max-width: 100%; height: 400px; width: 600px;"/></p><p style="text-indent: 2em; text-align: center;"><span style="font-size: 10px; font-family: 楷体, 楷体_GB2312, SimKai;">中国医学科学院肿瘤医院妇瘤科主任，北京协和医学院妇产科学系副主任、博士生导师吴令英教授做客新华网</span></p><p style="text-indent: 2em; text-align: left;"><strong>七成卵巢癌患者发现即是晚期</strong></p><p style="text-indent: 2em; text-align: left;">吴令英教授表示，由于卵巢深居盆腔，位置比较深，目前在国际上还没有找到早期筛查的有效方法。同时，卵巢癌早期一般没有特殊症状，如果出现不明原因的消瘦、腹胀、消化不好，往往已经进展到晚期，建议到医院做B超或是验血，检查肿瘤标志物。</p><p style="text-indent: 2em; text-align: left;">如果可以找到病因来预防卵巢癌是最理想的。研究显示，比较明确的病因是与遗传性相关的家族病史，例如遗传性乳腺癌-卵巢癌综合征，如家族中有直系亲属患有卵巢癌、乳腺癌，这个家族的其他女性就要引起注意，加强筛查?！案呶＜易宓呐砸膊恍枰缃猩覆椋悦飧∨?、年轻女性带来紧张焦虑，可以先请专业的医生咨询。”吴教授说。</p><p style="text-indent: 2em; text-align: left;">此外，吴教授还指出，预防卵巢癌的发生，健康的生活方式同样必不可少，均衡饮食，充足休息，避免通宵熬夜，避免高蛋白、高脂肪的食物，都有可能降低疾病的发生。</p><p style="text-indent: 2em; text-align: left;"><strong>PARP抑制剂为治疗卵巢癌提供新路径</strong></p><p style="text-indent: 2em; text-align: left;">吴令英教授表示，早期卵巢癌不易发现，但依靠手术就可实现临床治愈；中晚期患者除手术治疗外，往往还需要综合其它方面进行治疗，目前最常规的治疗手段为手术+化疗，但如果病程到了三、四期，两年复发率高达70%左右，五年生存率不足40%。</p><p style="text-indent: 2em; text-align: left;">吴教授表示，近两年PARP抑制剂逐渐成为治疗卵巢癌的新选择?！把芯糠⑾?，PARP抑制剂对于BRCA1/BRCA2的基因突变有显著效果，同时对HRD即同源重组修复通路障碍的患者也能取得一定疗效，相对于以往单纯性化疗来说，效果更好?！?/p><p style="text-indent: 2em; text-align: left;">PARP抑制剂在国际和国内的使用情况如何呢？吴教授介绍说，国际上，美国食品药品监督管理局（FDA）最早经临床研究，将PARP抑制剂批准用于携带gBRCA突变、三线及以上复发性卵巢癌患者的单药治疗。后经进一步III期临床研究，又将PARP抑制剂批准用于铂敏感复发性卵巢癌患者的维持治疗，2018年底基于SOLO1研究的结果，又进一步将PARP抑制剂批准用于BRCA突变、一线卵巢癌患者的维持治疗。“未来随着实验和研究的逐步深入，PARP抑制剂的使用范围也将会越来越广，获益人群也会越来越多。”</p><p style="text-indent: 2em; text-align: left;">国内方面，吴令英教授表示，我国也参与了一些全球多中心的临床研究，观察到了和国际上基本一致的临床结论，目前PARP抑制剂在国内也已被批准用于铂敏感复发性卵巢癌患者的维持治疗，2019年也有望获批一线维持治疗的适应症。未来我们也希望通过更加科学的研究，不断探索和完善PARP抑制剂的使用方法，让其更符合中国人的体质，达到更好的治疗效果。</p><p style="text-indent: 2em; text-align: left;"><strong>呼吁抗癌药纳入医保缓解患者治疗负担</strong></p><p style="text-indent: 2em; text-align: left;">去年，我国批准了首个卵巢癌靶向治疗药物PARP抑制剂，为对抗卵巢癌复发增添了新的“武器”。但新药往往价格昂贵，且未被纳入到我国医保目录，给患者带来了极大的经济负担。</p><p style="text-indent: 2em; text-align: left;">吴令英教授表示，很多抗癌药的价格相对其他药物来说价格昂贵，一般老百姓很难承受，希望未来能够在国家财力允许的情况下，将更多抗癌药物纳入医保，减少癌症患者“因病致贫”“因病返贫”的现象。</p><p style="text-indent: 2em; text-align: left;">“随着我国医保体系的逐步完善，抗癌药降价的推动力度也在不断提升。包括降税、减价等，这些对于加速抗癌药整体价格下降，以及加快进入医保有很大的帮助作用?！本萘私?，自去年5月起，我国已经实施了进口抗癌药零关税的政策，把17种临床急需、疗效好的抗癌药纳入了医保范围，降价幅度和力度均实现大幅提升。另据中国国家医疗保障局日前发布的消息称，截至2018年12月31日，全国医疗机构和药店按谈判价格采购17种国家谈判抗癌药总量约为184万粒（片/支），采购总金额5.62亿元，与谈判前价格相比节省采购费用9.18亿元，累计报销人次4.46万人次，报销金额2.56亿元，医保报销后费用负担降低超过75%。</p><p style="text-indent: 2em; text-align: left;">吴令英教授表示，降低药品价格，加快药品审批等都是抗癌药新政的具体措施。从妇科肿瘤疾病的层面分析，在临床上需求量很大的就是PARP抑制剂，希望今后通过抗癌药审批流程的简化，能够降低药品的价格，为百姓带来更多实惠。</p> </div> <p class="Editor">编辑：董雨吉 </p> <div id="i2i2jyu4k" class="Paging"> </div> <p class="Keyword">关键词：卵巢治疗 parp 抑制剂吴令英</p> <h1 class="pv_title_2 mt_15"><a href="/index.shtml" target="_blank" class="more mtb_14">更多</a><span id="i2i2jyu4k" class="t" id="a3"><a href="/index.shtml"><img src="/images/xg_t1.jpg" /></a></span></h1> <div id="i2i2jyu4k" class="pa_0_5_0_10"> <ul class="Related_ul bh_150"> <li><a target="_blank" href="/c/2017-07-04/1633908.shtml">七成卵巢癌发现均为晚期基因检测可减少发病风险</a></li> <li><a target="_blank" href="/c/2018-04-08/2018304.shtml">实际年龄≠卵巢生物年龄精油养护卵巢不靠谱</a></li> <li><a target="_blank" href="/c/2017-06-28/1620805.shtml">卵巢癌患者仅两成做过BRCA基因检测</a></li> <li><a target="_blank" href="/c/2018-03-22/2003041.shtml">女性到底该不该筛查卵巢癌</a></li> <li><a target="_blank" href="/c/2018-12-26/2249416.shtml">21岁姑娘卵巢像50岁卵巢早衰有哪些信号？</a></li> <li><a target="_blank" 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