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style="">昆药集团：与青蒿结缘创造生命奇迹</span> </h1> <script>/*jQuery('#hh').width(jQuery('#a').width());*/</script> <div id="i2i2jyu4k" class="Remark"> <span>2019年06月19日 09:53 | 来源：<a target="_blank">新华网</a></span> <span id="i2i2jyu4k" class="fr"> <div id="i2i2jyu4k" class="bdsharebuttonbox"><a href="#" class="bds_more" data-cmd="more"></a><a href="#" class="bds_qzone" data-cmd="qzone" title="分享到QQ空间"></a><a href="#" class="bds_tsina" data-cmd="tsina" title="分享到新浪微博"></a><a href="#" class="bds_tqq" data-cmd="tqq" title="分享到腾讯微博"></a><a href="#" class="bds_renren" data-cmd="renren" title="分享到人人网"></a><a href="#" class="bds_weixin" data-cmd="weixin" title="分享到微信"></a></div> <script>window._bd_share_config={"common":{"bdSnsKey":{},"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":"0","bdSize":"16"},"share":{}};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')).src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];</script> </span><span id="i2i2jyu4k" class="fr">分享到：<img src="/images/fx.jpg" /> </span> </div> <div id="i2i2jyu4k" class="text_box"> <p align="center"> <p style="text-indent: 2em; text-align: left;">作为青蒿素的发现者，屠呦呦教授及其团队为国际抗疟事业的发展做出了卓越贡献。作为全球第一家青蒿素生产企业，昆药集团有幸与屠呦呦团队、中国中医科学院中药研究所、中国军事医学科学院等单位携手合作，参与并见证了青蒿素的全球普及之路，并持续在抗疟领域及新适应症领域进行深入研究及探索。</p><p style="text-indent: 2em; text-align: left;">不解之缘从“523”项目开始</p><p style="text-indent: 2em; text-align: left;">20世纪60年代，在氯喹抗疟失效、人类饱受疟疾之害的情况下，中国启动了一项代号523的项目，该项目动用了超过60家科研机构及大约500名科学家，旨在研发一种新的抗疟疾药物。当时，昆药集团的前身昆明制药厂作为全国唯一一家企业，参与了此项研发工作，与全国科研专家共同踏上了研制抗疟新药的艰辛之路。</p><p style="text-indent: 2em; text-align: left;">在1979-1983年四年的时间里，昆药工作人员在简陋的实验室里进行了数千次的实验，并对各种数据、资料进行收集整理。1984年，昆药成立了中试车间，经过8年奋战，1987年国家批准了昆药集团生产蒿甲醚原料和蒿甲醚注射液两个一类新药。</p><p style="text-indent: 2em; text-align: left;">1990年，昆药集团再度深入探索抗疟之路，与中国军事医学科学院携手联合研发蒿甲醚复方型抗疟特效药，形成A+B新复方，该组方是全球第一个ACT固定比例复方药，开创了ACT药物开发及应用的先河，昆药成为全球第一家以青蒿素类药物为基础进行疟疾治疗方法（ACT疗法）研究的企业。</p><p style="text-indent: 2em; text-align: left;">深入研发拯救全球千万生命</p><p style="text-indent: 2em; text-align: left;">疟疾与世界上近一半人口的健康息息相关，更是受到国际社会广泛关注的全球公共卫生问题。目前，昆药生产的复方蒿甲醚已成为全球援助非洲的首选药物，挽救了全球上千万人的生命。</p><p style="text-indent: 2em; text-align: left;">昆药对复方蒿甲醚的研究从上世纪80年代开始，1987年，昆明制药厂（昆药集团前身）与军科院五所签署合作协议联合开发复方蒿甲醚，并于1992年获得我国新药证书。经过坚持不懈实践，1998年，复方蒿甲醚以商品名“Coartem”进入全球市场，成为中国原创新药取得国际专利的先例。</p><p style="text-indent: 2em; text-align: left;">2004年，昆药与军科院携手合作，成功研制出新一代复方抗疟药ARCO（复方磷酸萘奈酚喹片）。目前，昆药集团拥有七个蒿甲醚系列产品品种，参与起草制定的5个蒿甲醚系列药品质量标准（青蒿素、蒿甲醚、蒿甲醚片、蒿甲醚胶囊、蒿甲醚注射液）收载于国际药典标准。其中，生产的复方蒿甲醚系列药剂已成为全球主要的抗疟药，其针剂主要出口南美、非洲、南太平洋地区，拯救了全球特别是发展中国家数千万的生命，同时，蒿甲醚等抗疟制剂已在全球35个国家登记注册。</p><p style="text-indent: 2em; text-align: left;">加大投入推进青蒿素国际发展之路</p><p style="text-indent: 2em; text-align: left;">在疟疾威胁人群中，妊娠妇女和儿童是昆药在抗疟领域研发中重点关注的对象。昆药不断投入针对儿童、妊娠妇女抗疟药剂型及种类的研发，并不断推进新型抗疟药的研发，以助力实现全球疟疾相关儿童、孕产妇死亡率降低的目标。</p><p style="text-indent: 2em; text-align: left;">为加速推动国际抗疟事业的发展，2018年盖茨基金会与昆药正式签订合作协议，帮助昆药的科泰复产品通过世界卫生组织预认证，助力公司成为符合世卫质量标准的双氢青蒿素哌喹片全球采购的供应商，努力为全球疟疾患者提供更为安全且质量可靠的药品。</p><p style="text-indent: 2em; text-align: left;">除了抗疟领域，昆药集团还进一步加大了青蒿素产品的二次开发力度。2016年，昆药集团出资7000万元，与中国中医科学院中药研究所及屠呦呦团队再次合作，共同开发“双氢青蒿素片新适应症-红斑狼疮”项目。目前该项目已进入临床二期，若能进一步取得临床试验成功，将填补红斑狼疮有效治疗领域的空白，为人类治疗免疫性疾病作出重大贡献。</p><p style="text-indent: 2em; text-align: left;">未来，昆药将持续投入更多资源和力量，继续推进青蒿素的国际化发展之路，并以优势产品和技术为主导，加强与各大科研机构、高等院校合作，引进国内外优质资源和人才，把更多的优秀药品推向世界，向世人展示中国人民智慧的结晶。</p> </div> <p class="Editor">编辑：董雨吉 </p> <div id="i2i2jyu4k" class="Paging"> </div> <p class="Keyword">关键词：昆药全球甲醚抗疟</p> <h1 class="pv_title_2 mt_15"><a href="/index.shtml" target="_blank" class="more mtb_14">更多</a><span id="i2i2jyu4k" class="t" id="a3"><a href="/index.shtml"><img 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