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class="jiathis_button_qzone"></a> <a class="jiathis_button_tsina"></a> <a class="jiathis_button_tqq"></a> <a class="jiathis_button_weixin"></a> <a class="jiathis_button_renren"></a> <a class="jiathis jiathis_txt jtico jtico_jiathis" target="_blank"></a> </div> <script type="text/javascript" src="http://v3.jiathis.com/code_mini/jia.js?uid=1399539302485450" charset="utf-8"></script> </span><span id="i2i2jyu4k" class="fr">分享到：<img src="/images/fx.jpg" /> </span> </div> <div id="i2i2jyu4k" class="text_box"> <p align="center"> <p style="text-indent: 2em; text-align: left;">2014年7月1日至2015年6月30日，注射用抗生素头孢硫脒在全国已报告5802起不良反应事件，其中近3成受害者，是6岁以下儿童。</p><p style="text-indent: 2em; text-align: left;">上周，国家食品药品监督管理总局针对注射用头孢硫脒发出“警示”，提醒相关企业、医务人员和公众，关注头孢硫脒引起的过敏性休克等严重不良反应。</p><p style="text-indent: 2em; text-align: left;"><strong>头孢硫脒在中国使用广泛</strong></p><p style="text-indent: 2em; text-align: left;">头孢硫脒是我国自主研发的全身抗感染药，是广州白云山制药股份有限公司研发的拳头产品,在我国被广泛使用。记者查询国家食药监总局官网获悉，目前有17家企业生产35种头孢硫脒，市面上有广州白云山天心制药股份有限公司生产的头孢硫脒（阿威欣）、广州白云山医药集团股份有限公司白云山制药总厂生产的头孢硫脒（仙力素）等。</p><p style="text-indent: 2em; text-align: left;">解放军309医院药剂科主管药师西娜介绍，社区获得性肺炎、扁桃体炎等常见病，开放性骨折、烧伤等外伤性感染，头孢硫脒都是常用药，尤其是对抗肠球菌有非常显著的效果，比如肠道感染等，一般为注射给药。</p><p style="text-indent: 2em; text-align: left;"><strong>过敏性休克是常见严重不良反应</strong></p><p style="text-indent: 2em; text-align: left;">注射用头孢硫脒的不良反应临床表现主要包括瘙痒、荨麻疹、斑丘疹、呕吐、腹泻、皮疹、高热、寒战、心悸、胸闷、呼吸困难、过敏样反应、过敏性休克等表现。其中，上述后8种表现属于严重过敏反应。儿童患者严重不良反应临床表现主要有皮疹、瘙痒、寒战、高热、过敏性休克、过敏样反应、紫绀、呼吸困难等。</p><p style="text-indent: 2em; text-align: left;"><strong>严重不良反应多因超剂量</strong></p><p style="text-indent: 2em; text-align: left;">此次通报的数据显示，一年来，277起注射用头孢硫脒严重不良反应/事件中，引起的过敏性休克及儿童用药风险，半数（133例）病例存在不按说明书用法用量使用的情况，包括单次超剂量、日剂量超量给药，未分次给药等。</p><p style="text-indent: 2em; text-align: left;">注射用头孢硫脒不良反应/事件的儿童报告较多，其中6岁以下儿童报告1677例，占该品种总报告数28.9%。53.9%的儿童患者用药频率为一日一次，不符合药品说明书规定的分2-4次给药。</p><p style="text-indent: 2em; text-align: left;">西娜指出，头孢硫脒的半衰期约1小时，如此短的半衰期，需要一天分次给药才能起到一定的杀菌效果，故很有必要在临床使用时加以强调和规范，既可以保证药物的疗效，又可以减少不良反应的发生及耐药菌的滋生。</p><p style="text-indent: 2em; text-align: left;"><strong>建议：孩子生病，切勿盲目依赖抗生素</strong></p><p style="text-indent: 2em; text-align: left;">国家食药监总局提示：注射用头孢硫脒易发生严重过敏反应，如过敏性休克，医务人员在使用本品前应详细询问患者的过敏史，对本品所含成分过敏者禁用，过敏体质者慎用；医务人员使用头孢硫脒，特别是在给儿童用药时，须严格遵循药品说明书，将每日推荐剂量分次使用，避免单次给药剂量过大或每日总量超剂量。</p><p style="text-indent: 2em; text-align: left;">全国合理用药监测专家孙忠实教授仍然提醒公众，包括头孢硫脒在内的多种抗生素，不仅有不良反应风险，还有耐药风险，患者特别是儿童家长，切忌把抗生素当做万能药而滥用。</p><p style="text-indent: 2em; text-align: left;">为警示用药风险，国家食药监总局要求，注射用头孢硫脒相关生产企业应及时修订完善药品说明书，明示该药品在使用中可能存在的过敏性休克等严重不良反应，并做好不良反应监测和报告。</p><p style="text-indent: 2em; text-align: left;"><strong>■ 小贴士</strong></p><p style="text-indent: 2em; text-align: left;"><strong>孩子生病，家长如何判断是否用抗生素？</strong></p><p style="text-indent: 2em; text-align: left;">解放军309医院药剂科主管药师西娜：</p><p style="text-indent: 2em; text-align: left;">无指征、错误或长期使用抗生素对儿童身体的危害都会很大，容易导致其自身免疫力减退、肝肾功能受损、肠道菌群失调甚至发育减缓，不仅如此，孩子发生消化系统或药物过敏等不良反应、以及产生耐药性的几率也会明显增加。</p><p style="text-indent: 2em; text-align: left;">带孩子看病时，家长要听医生建议，在医生明确诊断后确定是否使用抗生素。病毒引起的感冒、喉咙痛、急性支气管炎、腹泻等均不需要使用抗生素。</p><p style="text-indent: 2em; text-align: left;">建议孩子生病必须使用抗生素时，首选口服剂型，其次是肌注，最后才是静脉点滴，以减少药物对孩子身体的危害。新京报讯（记者王卡拉）</p><p style="text-indent: 2em; text-align: left;"><strong>■ 行业医疗</strong></p><p style="text-indent: 2em; text-align: left;"><strong>陪诊也“移动”</strong></p><p style="text-indent: 2em; text-align: left;">新京报讯（记者张秀兰）在挂号与慢性疾病管理之外，移动医疗服务已经开始渗透医疗服务的其他环节。今年上线的安心陪诊，依托三甲医院护士，以App、微信等方式实现患者线上下单，线下提供医院取号、就诊陪护等服务，旨在缩短患者就医时间、提高就医效率和改善患者及家属就医体验的效果。北京陪诊医家科技有限公司总裁吴建华表示，外地患者、儿童、孕妇以及老年人群体是首批重点服务人群。</p><p style="text-indent: 2em; text-align: left;"><strong>7人防治“老年痴呆”获奖</strong></p><p style="text-indent: 2em; text-align: left;">新京报讯（记者王卡拉）12月13日，“全国阿尔茨海默病防治科学人物奖”颁奖大会在北京召开。阿尔茨海默病防治协会在全国广泛征集了各界人士的意见，最终推荐出了7名获奖者，分别为北京协和医院顾方舟、卫生部北京医院许贤豪、北京宣武医院研究员盛树力、中国工程院院士唐希灿、北京交通大学生命科学与生物工程研究员王军、北京宣武医院李坤成、中国科技大学生命科学院申勇。</p><p><br style="text-indent: 2em; text-align: left;"/></p> </div> <p class="Editor">编辑：赵彦 </p> <div id="i2i2jyu4k" class="Paging"> </div> <p class="Keyword">关键词：儿童抗生素 ?；?#32;过敏性休克不良反应</p> <h1 class="pv_title_2 mt_15"><a href="/index.shtml" target="_blank" class="more mtb_14">更多</a><span id="i2i2jyu4k" class="t" id="a3"><a href="/index.shtml"><img src="/images/xg_t1.jpg" /></a></span></h1> <div id="i2i2jyu4k" class="pa_0_5_0_10"> <ul class="Related_ul bh_150"> <li><a target="_blank" href="/c/2015-12-14/649049.shtml">家家都能种的4种抗病植物你知道吗</a></li> <li><a target="_blank" href="/c/2015-12-14/649034.shtml">93岁老中医一辈子离不开1种食物</a></li> <li><a target="_blank" href="/c/2015-12-14/649029.shtml">中国首张互联网医院在线处方诞生</a></li> <li><a target="_blank" href="/c/2015-12-14/649020.shtml">做饭加香料大脑更健康欧芹、甘菊、红辣椒等</a></li> <li><a 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