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class="Content_title" id="hh"> <span id="a" style="">多年备孕失败竟因免疫异常</span> </h1> <script>/*jQuery('#hh').width(jQuery('#a').width());*/</script> <div id="i2i2jyu4k" class="Remark"> <span>2018年08月20日 11:02 | 作者:翁淑贤 | 来源：<a target="_blank">广州日报</a></span> <span id="i2i2jyu4k" class="fr"> <div id="i2i2jyu4k" class="bdsharebuttonbox"><a href="#" class="bds_more" data-cmd="more"></a><a href="#" class="bds_qzone" data-cmd="qzone" title="分享到QQ空间"></a><a href="#" class="bds_tsina" data-cmd="tsina" title="分享到新浪微博"></a><a href="#" class="bds_tqq" data-cmd="tqq" title="分享到腾讯微博"></a><a href="#" class="bds_renren" data-cmd="renren" title="分享到人人网"></a><a href="#" class="bds_weixin" data-cmd="weixin" title="分享到微信"></a></div> <script>window._bd_share_config={"common":{"bdSnsKey":{},"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":"0","bdSize":"16"},"share":{}};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')).src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];</script> </span><span id="i2i2jyu4k" class="fr">分享到：<img src="/images/fx.jpg" /> </span> </div> <div id="i2i2jyu4k" class="text_box"> <p align="center"> <div style="text-indent: 2em; text-align: left;"><p style="text-indent: 2em; text-align: left;">不孕不育让很多育龄夫妇深陷烦恼，而除了长期备孕怀不上、生殖助孕反复失败，好不容易怀上了却发生胎停、流产、死胎等不良妊娠结果……在“造人”的历程中，不少女性尝遍了苦头。</p><p style="text-indent: 2em; text-align: left;">到底是什么原因挡住了“好孕”?广州医科大学附属第三医院风湿免疫科张建瑜提醒，免疫异常是不可忽视的因素之一！从临床观察来看，因免疫因素而导致的不孕症，已给不少女性造成了很大的危害。她建议，不明原因的长期不孕，尝试生殖助孕两次以上失败或有两次及以上不良妊娠结果的，在排除输卵管堵塞等身体结构异常的情况下，建议查一查免疫因素。</p><p style="text-indent: 2em; text-align: left;"><strong>女子备孕七年吃尽苦头竟是免疫异?！白魉睢?/strong></p><p style="text-indent: 2em; text-align: left;">来自海南的丘女士今年39岁了，7年前开始备孕的她，头几年尝试自然受孕，但一直迟迟没有动静。于是夫妻俩便转而求助于辅助生殖技术，没想到经历了三次人工受精、1次试管婴儿均以失败告终。</p><p style="text-indent: 2em; text-align: left;">就在丘女士准备做第二次试管婴儿移植之前，医生建议她做一个全身检查，结果显示她有结缔组织病、血沉高且风湿因子高。这些免疫异常丘女士之前并没有发现。风湿免疫科医师认为，丘女士属于免疫性不孕，这也解释了她为何多年备孕、生殖助孕失败。</p><p style="text-indent: 2em; text-align: left;">查明病因之后，医生为丘女士进行了免疫调节与抗凝治疗。经过半年多的调治，丘女士终于自然受孕，并自然分娩生下一个7斤重的健康男婴。</p><p style="text-indent: 2em; text-align: left;"><strong>提醒莫忽视免疫异常引起的不孕</strong></p><p style="text-indent: 2em; text-align: left;">广医三院风湿免疫科主任医师张建瑜观察发现，临床上，像丘女士这样不明原因反复受孕失败的育龄女性其实不在少数。她曾经接诊过一位33岁、已经备孕6年的女性，在经历了三次试管婴儿移植均告失败，后来做体检排查，查“风湿三项”结果发现免疫性异常，在进行了两个月的免疫调节后第四次做试管婴儿移植，终于成功受孕。</p><p style="text-indent: 2em; text-align: left;">“在不孕的诸多原因中，免疫性因素引起的不孕经常被忽视。”张建瑜指出，引起免疫异常的因素有多种，比如红斑狼疮，此外还有未分化结缔组织、抗磷脂综合征、NK细胞过高、干燥综合征等，但备孕屡屡失败的女性多数想不到迟迟未能降临的“好孕”跟这些病有关系。</p><p style="text-indent: 2em; text-align: left;"><strong>解读免疫细胞攻击胚胎致受孕困难</strong></p><p style="text-indent: 2em; text-align: left;">张建瑜说，免疫因素往往可引起全身性疾病?；吃星埃星痹诿庖咭斐５呐钥赡懿⒚挥腥魏紊硖宀皇?；当她们受孕时，作为外来物的“精子”刺激身体免疫系统，可引起“过激”反应，出现免疫系统攻击胚胎的情况。</p><p style="text-indent: 2em; text-align: left;">张建瑜解释，免疫系统作为抵御各种细菌病毒和外来病原体的系统，对于人的健康发挥着重要作用。但免疫系统也有“认错人、办错事”的时候，比如器官移植后发生的免疫排斥，免疫系统将新的器官当做“入侵者”，想把它“干掉”。免疫细胞攻击胚胎也是同样的道理。当免疫细胞把胚胎当做身体的“入侵者”时，便会对其发起攻击。这种攻击可能发生在胚胎进入女性子宫之时、胚胎刚刚着床的阶段，也可能发生在胎盘发育的阶段，从而出现胚胎着床失败、受孕难，或者即便怀上了，也容易在孕前三个月发生胎停、死胎或者流产等不良妊娠。</p><p style="text-indent: 2em; text-align: left;"><strong>建议莫名不孕或反复流产快排查是否免疫异常</strong></p><p style="text-indent: 2em; text-align: left;">张建瑜建议，如果女性发现自己不孕，排查没发现有结构性原因（如输卵管因素）、染色体原因、内分泌异常等，建议要加查是否存在免疫异常。对已发生两次及以上不良妊娠结果（如孕早期胎停、死胎、流产等），或是实施辅助生殖（人工受精、试管婴儿）两次及以上不成功的人群，建议也应排查是否为免疫因素引起。</p><p style="text-indent: 2em; text-align: left;">张建瑜提醒，已诊断为免疫因素引起的不孕女性，应先进行免疫治疗，主要包括免疫调节和抗凝治疗，在孕前及整个孕期都要有产科医生及免疫专科医生联手帮助严密监测。据她介绍，曾有一个“抗磷脂综合征”的女性在接受免疫调节后成功受孕，但孕期忽视了孕期免疫因素监测，孕22周便胎停了，令人遗憾。</p><p style="text-indent: 2em; text-align: left;">一般情况下，免疫治疗会从备孕期一直持续到孕14周，孕早期仍是高风险期，需要严密监测。有些患者怀孕后对吃药很排斥，担心免疫治疗的药物对胎儿有害，对此，张建瑜认为不必太过担心，因为风湿免疫科专科医生会根据孕妇个体免疫情况，有针对性地调节用药，确保母婴安全。</p><p style="text-indent: 2em; text-align: left;">医学指导/广州医科大学附属第三医院风湿免疫科主任医师张建瑜</p><p style="text-indent: 2em; text-align: left;">（全媒体记者翁淑贤通讯员白恬）</p></div> </div> <p class="Editor">编辑：赵彦 </p> <div id="i2i2jyu4k" class="Paging"> </div> <p class="Keyword">关键词：多年备孕失败免疫异常风湿免疫</p> <h1 class="pv_title_2 mt_15"><a href="/index.shtml" target="_blank" class="more mtb_14">更多</a><span id="i2i2jyu4k" class="t" id="a3"><a href="/index.shtml"><img src="/images/xg_t1.jpg" /></a></span></h1> <div id="i2i2jyu4k" class="pa_0_5_0_10"> <ul class="Related_ul bh_150"> <li><a target="_blank" href="/c/2018-05-17/2057501.shtml">川航惊魂始末机长刘传健还原细节</a></li> <li><a target="_blank" href="/c/2016-11-10/1136868.shtml">“双十一”盛宴，几多欢笑几多泪？——剖析电商“潜规则”</a></li> <li><a target="_blank" href="/c/2016-05-25/830665.shtml">女子称自己非父母亲生母亲：她不想赡养才撒谎</a></li> <li><a target="_blank" 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