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id="i2i2jyu4k" class="t" id="a1"><a href="/xywy/yxtqs/">医讯同期声</a></span></h1> <div id="i2i2jyu4k" class="pa_0_5_0_10"> <h1 class="Content_title" id="hh"> <span id="a" style="">"转基因表皮"让皮肤再获新生后期研究显示其功能完全正常</span> </h1> <script>/*jQuery('#hh').width(jQuery('#a').width());*/</script> <div id="i2i2jyu4k" class="Remark"> <span>2017年11月09日 09:08 | 作者:张梦然 | 来源：<a target="_blank">科技日报</a></span> <span id="i2i2jyu4k" class="fr"> <div id="i2i2jyu4k" class="bdsharebuttonbox"><a href="#" class="bds_more" data-cmd="more"></a><a href="#" class="bds_qzone" data-cmd="qzone" title="分享到QQ空间"></a><a href="#" class="bds_tsina" data-cmd="tsina" title="分享到新浪微博"></a><a href="#" class="bds_tqq" data-cmd="tqq" title="分享到腾讯微博"></a><a href="#" class="bds_renren" data-cmd="renren" title="分享到人人网"></a><a href="#" class="bds_weixin" data-cmd="weixin" title="分享到微信"></a></div> <script>window._bd_share_config={"common":{"bdSnsKey":{},"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":"0","bdSize":"16"},"share":{}};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')).src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];</script> </span><span id="i2i2jyu4k" class="fr">分享到：<img src="/images/fx.jpg" /> </span> </div> <div id="i2i2jyu4k" class="text_box"> <p align="center"> <div style="text-indent: 2em; text-align: left;"><p style="text-indent: 2em; text-align: left;">英国《自然》杂志8日发表的一篇医学研究论文称，欧洲科学家通过移植转基因表皮培养物，使一位7岁的交界型大疱性表皮松解症（JEB）患者全身约80%的皮肤获得重建，且后期研究显示其皮肤功能完全正常。</p><p style="text-indent: 2em; text-align: left;">交界型大疱性表皮松解症是一种严重的可致皮肤发生松弛的遗传疾病，常具有致命性。此前研究表明，名为LAMA3、LAMB3或LAMC2的基因突变，会影响层黏连蛋白332（表皮基底膜的一种组分），导致患者皮肤出现大疱和慢性伤口。该病不仅严重影响患者生活质量，还可能引起皮肤癌。</p><p style="text-indent: 2em; text-align: left;">过去对两名患者的治疗证明，移植转基因表皮培养物，也就是一种基因改造的表皮细胞群，能够生产功能正常的表皮，修复交界型大疱性表皮松解症的皮肤损害。但以往只能重建一些小面积范围内的皮肤。</p><p style="text-indent: 2em; text-align: left;">此次，面对一名年仅7岁的患者，意大利摩德纳雷焦艾米利亚大学科学家团队利用患者身体上无大疱区域的皮肤细胞，培养了原代角化细胞，再利用逆转录病毒载体对其进行基因改造，抑制LAMB3基因的非突变形式，借此重建表皮。随后，研究人员将转基因表皮移植物敷在准备好的真皮创伤部位，覆盖患者受影响的体表。</p><p style="text-indent: 2em; text-align: left;">在接下来的21个月里，团队发现其再生的表皮紧密地附着在下层真皮上，甚至在受到诱导发生机械应力作用后，也能正常愈合，没有形成大疱。</p><p style="text-indent: 2em; text-align: left;">论文作者通过克隆跟踪发现，这些人体表皮靠有限数量的长寿干细胞维持，这些细胞普遍能自我更新，生成祖细胞并补充末分化的角化细胞。</p></div> </div> <p class="Editor">编辑：赵彦 </p> <div id="i2i2jyu4k" class="Paging"> </div> <p class="Keyword">关键词：转基因表皮皮肤再获新生</p> <h1 class="pv_title_2 mt_15"><a href="/index.shtml" target="_blank" class="more mtb_14">更多</a><span id="i2i2jyu4k" class="t" id="a3"><a href="/index.shtml"><img src="/images/xg_t1.jpg" /></a></span></h1> <div id="i2i2jyu4k" class="pa_0_5_0_10"> <ul class="Related_ul bh_150"> <li><a target="_blank" 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