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<span>2017年04月07日 14:23 | 来源：<a target="_blank">中国医药报</a></span> <span id="i2i2jyu4k" class="fr"> <div id="i2i2jyu4k" class="bdsharebuttonbox"><a href="#" class="bds_more" data-cmd="more"></a><a href="#" class="bds_qzone" data-cmd="qzone" title="分享到QQ空间"></a><a href="#" class="bds_tsina" data-cmd="tsina" title="分享到新浪微博"></a><a href="#" class="bds_tqq" data-cmd="tqq" title="分享到腾讯微博"></a><a href="#" class="bds_renren" data-cmd="renren" title="分享到人人网"></a><a href="#" class="bds_weixin" data-cmd="weixin" title="分享到微信"></a></div> <script>window._bd_share_config={"common":{"bdSnsKey":{},"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":"0","bdSize":"16"},"share":{}};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')).src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];</script> </span><span id="i2i2jyu4k" class="fr">分享到：<img src="/images/fx.jpg" /> </span> </div> <div id="i2i2jyu4k" class="text_box"> <p align="center"> <div style="text-indent: 2em; text-align: left;"><p style="text-indent: 2em; text-align: left;">研究发现母乳低聚糖有助于新生儿清除感染性病原体，英国的研究人员认为，这特别有助于增强婴儿的免疫系统功能。伦敦帝国理工学院的研究人员发现，乳糖基-N-二岩藻黄素六糖I（LNDFHI）有助于新生儿在出生后几周内清除B族链球菌，B组链球菌是产后新生儿脑膜炎的常见感染原因，也是英国甚至全球的新生儿在出生后最初三个月里感染的主要原因。研究人员希望这些新知识能够有助于开发预防母婴感染的治疗方法。</p><p style="text-indent: 2em; text-align: left;">多项研究表明，母乳能够预防过敏和疾病，研究人员介绍说，母乳中的糖也可以防止其他有害细菌引发的感染，有助于新生儿未发育成熟的免疫系统。低聚糖是在母乳中发现的一种糖，其不会在新生儿肠道中被消化，而是在新生儿肠道内为益生菌提供营养，并作为他们的肠道微生物菌群，肠道微生物菌群可在身体一系列基本功能中发挥作用。</p><p style="text-indent: 2em; text-align: left;">大约三分之一女性的肠道和阴道中携带B族链球菌，可以在分娩时或通过乳汁传递给新生儿。体内能够生成LNDFHI（其生成受Lewis抗原系统的调控）的女性，肠道内携带细菌的可能性较小，她们的孩子感染这些细菌的可能性也较小。伦敦帝国理工学院研究员Nicholas Andreas博士称：“如果我们知道母亲是否定殖B族链球菌，并知道她是否携带Lewis基因的活性复制，那么这可能会提示我们，她将细菌传递给孩子的可能性，从而可以采取更多个性化的预防措施”。</p><p style="text-indent: 2em; text-align: left;">该研究发表在《Clinical and Translational Immunology》杂志上，研究人员招募了183位母亲及其婴儿进行研究，分析了109份初乳样本、61份出生后6天采集的母乳样本和63份出生后3个月采集的母乳样本。对于在研究期间所有时间点均无法提供母乳样本的女性，有33.7%的母亲定殖B族链球菌，其中，52%可将B族链球菌传递给新生儿，导致17.5%新生儿被定殖B族链球菌。</p><p style="text-indent: 2em; text-align: left;">母乳中含有糖，糖可作为病原体的诱饵，让病原体误认为它已经侵入人体细胞，而实际上则不然，之后细菌被排出体外，从而不会导致人体感染。糖还能够促进肠道微生物菌群和免疫系统发育所需细菌的增殖。</p><p style="text-indent: 2em; text-align: left;">目前，研究人员认为其他糖类可能会以类似方式抵御其他感染，研究人员正在计划开展研究，以考察对于没有活性Lewis基因（因此没有活性Lewis抗原系统）的女性，给予特定补充剂能否帮助预防新生儿B族链球菌感染和其他危险的感染。</p><p style="text-indent: 2em; text-align: left;">Andreas博士称：“虽然这只是早期研究，但结果证实了母乳的复杂性，以及它可能为新生儿带来的益处。越来越多的研究表明，母乳中的糖（人乳低聚糖）可以保护新生儿免受感染，如轮状病毒和B族链球菌，并可促进新生儿体内肠道益生菌的增殖”。（胡嘉骏）</p></div> </div> <p class="Editor">编辑：赵彦 </p> <div id="i2i2jyu4k" class="Paging"> </div> <p class="Keyword">关键词：母乳低聚糖新生儿免受感染</p> <h1 class="pv_title_2 mt_15"><a href="/index.shtml" target="_blank" class="more mtb_14">更多</a><span id="i2i2jyu4k" class="t" id="a3"><a href="/index.shtml"><img src="/images/xg_t1.jpg" /></a></span></h1> <div id="i2i2jyu4k" 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